Pycnogenol®, a standardized extract of the bark of the French P. pinaster (Pinus pinaster Ait. Subsp. atlantica), has been used worldwide as a herbal remedy. Maritime pine bark extract is used for asthma, high cholesterol, decline in memory, ADHD, and many other conditions, but there is no good scientific evidence to. Pine bark extract is an herbal supplement rich in healthy polyphenols like procyanidins, catechins, and phenolic acids. These plant compounds. LG 21 9 ULTRAWIDE To use our made possible by. To enable session he had no Enable session logging fix bugs before you can easily. Get this limited-time.
The results have shown that the fluidity of erythrocyte was increased predominantly at the membrane surface PBE showed preventive effects against edema during long flights. The assessment of flight-edema was performed by evaluating an analogue scale, the rate of ankle swelling by strain-gauge derived rate of ankle swelling, and by assessing the ankle circumference variation PBE can also be used for prevention and treatment of chronic venous insufficiency CVI and related venocapillary disturbances.
Chronic venous insufficiency causes venous hypertensive microangiopathy leading to venous ulcerations PBE was effective in improvement of the legs heaviness and subcutaneous edema and in reduction of venous pressure in patients with CVI. These clinical effects of PBE might be due to the stabilizing the collagenous subendothelial basal membrane or scavenging the free radicals or by the combination of these activities Edema is very common in hypertensive patients under treatment.
Belcaro et al. Supplementation with PBE rich in polyphenols has favorable effects on two risk factors for coronary artery disease, i. It was reported that PBE increased plasma antioxidant capacity determined by oxygen radical absorbance capacity and altered plasma lipoprotein profile especially, reduction of bad cholesterol LDL in human volunteers The total cholesterol decreased from 5. The levels of thromboxane B 2 the main plasma thromboxane A 2 metabolite were assessed in animal model of insulin-dependent diabetes by enzyme-linked immunosorbent assay.
Diabetes mellitus is an endocrine disorder, and its complications such as dyslipidemia elevated levels of total cholesterol, LDL, and triglycerides and a low concentration of HDL and hyperglycemia are a major cause of disability and hospitalization, posing a significant financial burden Chronic hyperglycemia of uncontrolled diabetes mellitus increases reactive oxygen species oxidative stress and decreases enzymatic antioxidant defenses responsible for retinopathy and cataract formation.
This chronic disease may lead to microvascular pathologies, especially in the eye, kidney, and peripheral nerve It was also reported that PBE reduced menstrual cramps, abdominal pain and tenderness in gynecological disorders such as endometriosis and dysmenorrhea, and could be used as a therapeutic alternative to gonadotropin releasing hormone agonist Gn-RHa in the treatment of endometriosis 73 , Polyphenolic compounds rich PBE has beneficial effects in a series of painful conditions such as stiff shoulder, herniated disc, and pregnancy associated pain lower back pain, hip joint pain, pain in the inguinal region, and pain due to varices or calf cramps The analgesic and antispasmodic effects of medicinal herbs may have suitable effects on menstrual cramps and premenstrual syndrome Two polyphenolic components of PBE caffeic and protocatechuic acids have non-specific antispasmodic action on smooth muscle in several organs of the rat.
It seems that this antispasmodic effect may contribute in beneficial effects of PBE in premenstrual syndrome Polyphenols rich extract like PBE reduces hyperactivity of children, catecholamine excretion, and oxidative stress 5 , PBE rich in procyanidins inhibited not only the binding of human immunodeficiency virus type-1 HIV-1 to host cells but also inhibited HIV viral replication and T-cell interaction in cell culture experiments PBE was found to induce expression of an intracellular antioxidant protein and manganese superoxide dismutase, and inhibition of phosphorylation of the ribosomal S6 protein.
PBE is a promising agent for inhibi-tion of encephalomyocarditis viral replication, prevention of development of viral myocarditis, and improvement of inflamma-tion and myocardial necrosis. PBE was shown to have antimicrobial activity against various pathogenic prokaryotes gram negative and positive bacteria , and eukaryotes fungi and yeasts 83 , PBE rich in polyphenolic compounds has been shown to cause endothelium-dependent vasorelaxation and decrease the amount of circulating inflammatory substances in the blood stream.
Intake of PBE is useful in order to reduce the risk of heart disease and is effective in the treatment of chronic venous insufficiency and retinal micro-hemorrhages venous disorders. Anti-inflammatory and antioxidant activities of PBE have been demonstrated in vitro and in vivo. PBE also protects the nerve cells against beta-amyloid, or glutamate induced toxicity and the erythrocytes in G6PD deficiency. Immunomodulation has been observed in both animal models and patients with Lupus erythematosus.
Reduction of smoke-enhanced thromboxane B formation and platelet aggregation in response to cigarette smoking has also been reported. PBE inhibits angiotension-converting enzyme which is associated with a mild antihypertensive effect. Results from pharmacological and clinical studies have demonstrated that PBE can be used as a source of natural antioxidants in the food and pharmaceutical industries. However, more investigations are needed to confirm and extend the previous observations.
Previous studies suggested that bark extract obtained from P. We demonstrated that Iranian P. Therefore, these two Iranian Pinus species other than French P. Res Pharm Sci. Iravani 1 and B. Iran Find articles by S. Iran Find articles by B.
Author information Article notes Copyright and License information Disclaimer. Received Nov; Accepted Feb. This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3. This article has been cited by other articles in PMC.
Abstract In everyday life, our body generates free radicals and other reactive oxygen species which are derived either from the endogenous metabolic processes within the body or from external sources. Keywords: Pycnogenol, P. Open in a separate window. Antioxidant and free radical scavenging activities Inactivation of the superoxide and hydroxyl radical, and inhibition of singlet oxygen formation are two important beneficial effects of PBE 9 , 11 — Antioxidant and anti-inflammatory effects of Pinus pinaster bark extract.
Anti-inflammatory effects Several in vitro studies have revealed that PBE has anti-inflammatory effects and inhibits the initiation of inflammation by preventing the release of pro-inflammatory mediators regulated by oxidative stress. Cardiovascular system Zibadi and coworkers have reported that PBE resulted in improvement of type 2 diabetes controls and reduction of the risk factor of cardiovascular disease and antihypertensive medicine use in subjects with type 2 diabetes.
Venous disorders PBE showed preventive effects against edema during long flights. Cholesterol lowering effects Supplementation with PBE rich in polyphenols has favorable effects on two risk factors for coronary artery disease, i. Attention deficit hyperactivity disorder ADHD Polyphenols rich extract like PBE reduces hyperactivity of children, catecholamine excretion, and oxidative stress 5 , Antimicrobial and antiviral activity PBE rich in procyanidins inhibited not only the binding of human immunodeficiency virus type-1 HIV-1 to host cells but also inhibited HIV viral replication and T-cell interaction in cell culture experiments Zolfaghari B, Ghannadi A.
The principles and therapeutic uses of phytomedicinals- what every physician must know. Res Med Sci J. Gulati OP. The nutraceutical Pycnogenol: its role in cardiovascular health and blood glucose control. Biom Rev. Phytother Res. Mol Brain Res. Pycnogenol as an adjunct in the management of childhood asthma.
J Asthma. Rohdewald P. A review of the French maritime pine bark extract Pycnogenol , a herbal medication with a diverse clinical pharmacology. Int J Clin Pharmacol Ther. Antioxidant activity and biologic properties of a procyanidin-rich extract from the pine Pinus maritima bark, Pycnogenol. Free Rad Biol Med. J Agric Food Chem. An anti-inflammatory and superoxide radical scavenging activities of a procyanidins containing extract from the bark of Pinus pinaster sol. Pharm Parmacol Lett.
Gouchang Z. Ultraviolet radiation-induced oxidative stress in cultured human skin fibroblasts and antioxidant protection. Biol Res Rep Univ. Biochem Mol Biol Int. The effect of Pycnogenol on the erythrocyte membrane fluidity. Gen Physiol Biophys. Ferritin oxidation and proteasomal degradation: Protection by antioxidants. Free Radic Res. Pycnogenol enhances endothelial cell antioxidant defenses. Redox Rep. Pycnogenol protects vascular endothelial cells from t-butyl hydroperoxide induced oxidant injury.
Biotech Ther. Pycnogenol inhibits macrophage oxidative burst, lipoprotein oxidation, and hydroxyl radical-induced DNA damage. Drug Dev Ind Pharm. Plasmid vector pBR and its special-purpose derivatives--a review. Back to basics: pBR and protein expression systems in E. Methods Mol Biol. J Clin Biochem Nutr. The combined effect of pycnogenol with ascorbic acid and trolox on the oxidation of lipids and proteins.
FEBS Lett. Procyanidins from Pinus maritima bark: Antioxidant activity, effects on the immune system and modulation of nitrogen monoxide metabolism. Antioxidant Food Supplements in Human Health. Pine bark extract has a significant impact on nitric oxide NO levels in the body, which are responsible for vasodilation and improving blood flow.
A recent study found the combination of pine bark extract and arginine an amino acid that also boosts NO production were effective for improving mild to moderate erectile dysfunction. Pine bark extract may provide some added benefits for you if you struggle with high blood sugar, pre-diabetes, or diabetes. A double blind, placebo-controlled study of 77 diabetic patients taking their prescription medications, along with mg of supplemental Pycnogenol, found greater improvement in blood sugar control and cardiovascular health when pine bark extract was combined with diabetic medications.
There is nothing more annoying than a nagging cold; it stalls your productivity at work and in the gym. A study of people suffering from a common cold found supplementing with Pycnogenol was able to reduce the duration i.
Stress, poor diet, and lack of sleep can all contribute to sub-optimal brain function, and while diet and exercise are fantastic for boosting healthy brain function, so too is pine bark extract. New research shows that adults over the age of 55, supplementing with Pycnogenol over the course of one year, showed superior results in brain related tasks compared to placebo groups.
Getting enough sun exposure and vitamin D is crucial for your health and vitality. New research shows that not getting enough sun exposure is as dangerous to your health as smoking. The addition of supplemental pycnogenol has been shown to offer protection from harmful UVB rays and may reduce hyperpigmentation and improve skin barrier function. Cytokines are a group of pro-inflammatory molecules that are released when you get a cold or flu, suffer from a fall or injury or train too hard in the gym!
Research shows that pine bark extract is capable of reducing pro-inflammatory cytokines IL-1 and IL-6, responsible for many of the adverse effects of chronic inflammation. Pine bark extract can make a great addition to your nutritional arsenal for its potent antioxidant support, as well as its added support for blood flow, blood sugar, inflammation, immunity, brain function and skin support.
Remember, a good diet and regular exercise should always be the foundation for building your best health. However, sometimes the body needs a little added support and supplemental Pycnogenol can go a long way to keeping your brain and body sharp this winter.
Want to stay in the know on wellness products and delicious recipes? Sign up for our e-newsletter. Improve Erectile Dysfunction Blood Flow Pine bark extract has a significant impact on nitric oxide NO levels in the body, which are responsible for vasodilation and improving blood flow. Balance Blood Sugars Pine bark extract may provide some added benefits for you if you struggle with high blood sugar, pre-diabetes, or diabetes.
Fight Off Common Colds There is nothing more annoying than a nagging cold; it stalls your productivity at work and in the gym. Reduce Inflammation Cytokines are a group of pro-inflammatory molecules that are released when you get a cold or flu, suffer from a fall or injury or train too hard in the gym! By Dr.
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Bark extract air jordan qMaritime Pine Bark Extract with Dr. Ramon Velazquez, Ph.D. - Mind Lab Pro®
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